The outbreak of the COVID-19 pandemic has had a major impact on Indonesia's economic growth. One of the sectors that are affected is tourism. To boost the tourism industry, we must not forget Micro, Small, and Medium Enterprises (MSMEs) which are one of the supporters. During this pandemic, as many as 75% of MSME players admitted to experiencing a significant decline in sales. Most of these business actors do not have a plan in running the business. Therefore, training is usually quite often targeting MSMEs with the aim of increasing the competence of MSME actors to survive in the current digital era. One of the trainings provided for external users by CELOE Telkom University through Open Online Learning is for MSMEs in super-priority destinations of Yogyakarta and Lombok. Therefore, the purpose of this study is to see what E-learning success factors in the implementation of online training conducted by Telkom University. This study tests a conceptual framework using survey data of 60 MSMEs super-priority destinations of Yogyakarta and Lombok and employing structural equation model (SEM) analysis from a partial least square (PLS) approach. The results show that there are two variables that do not influence the system use, they are system quality dan information quality. System users do not understand the system applied in this training, especially in operating the system. Respondents said that the obstacles faced in implementing the system were due to the lack of participation of system users in the training and the lack of user experience in using the E-Learning system. The quality of the system does not have a positive effect on usability because the system is mandatory so the users do not have any other options and no choices. Hence, the research result also can be used to evaluate the success of organizational E-Learning systems from learner perspectives. This evaluation can provide fast and early feedback for Telkom University and take corrective actions if necessary for improvement.